Chymotrypsin is roughly the identical as trypsin. Each are concerned in protein amino acid metabolism enzymes, but in addition a hydrolase. Chymotrypsin is a proteolytic enzyme secreted by the pancreas and might rapidly decompose denatured proteins. Its motion and use are just like that of enzyme trypsin. It has stronger decomposing means, decrease toxicity and fewer opposed reactions than trypsin. The usage of chymotrypsin is broadly used and can be utilized for sprain, otitis media, rhinitis, sinusitis, pharyngitis, lung abscess and different therapies. It Can be utilized for surgical irritation, trauma, hematoma and abscess, and so forth., it will also be used for tracheotomy. Chymotrypsin has a superb impact on many sufferers, making it simpler for cough.
Pharmacological results of chymotrypsin The peptide chains of protein macromolecules will be cleaved into smaller molecular weight peptides, or act on the peptide ends of protein molecules to separate amino acids, and sure lipids will be hydrolyzed. Via this motion, fibrin and mucin will be hydrolyzed into polypeptides or amino acids within the sputum, making the viscous sputum liquefied and simple to cough up. It’s efficient for purulent or non-pyogenic sputum. As well as, chymotrypsin can chill out the ciliary ligament and dissolve the protein construction of sure tissues within the eye. Chymotrypsin additionally promotes the penetration of antibiotics and chemotherapeutic medicine into lesions. Precautions 1.Intramuscular injections of chymotrypsin have to be finished earlier than allergy assessments and intravenous injections are prohibited. 2.If allergic reactions happen, it must be stopped instantly and handled with antihistamines. 3.Chymotrypsin has a robust toxicity to the retina. As a result of it might probably trigger crystal injury, don’t let its liquid penetrate into the vitreous object. 4.The chymotrypsin is quickly inactivated by blood, so there should be no coagulation of blood on the website of administration 5.The chymotrypsin is steady within the strong state, however its resolution is unstable. It might lose 50% of its exercise after being left at room temperature for 9 days. Due to this fact, solely confect it earlier than the minute you need to use it. 6.The signs of glaucoma attributable to chymotrypsin could also be relieved by means of beta-blockers (akin to timolol) or oral carbonic anhydrase inhibitors (akin to acetazolamide) after the operation. 7.For the reason that titration of chymase was considerably decreased after ultrasonic nebulization, the inhalation time of chymotrypsin ultrasonic atomization must be managed inside 5 minutes. Hostile reactions: 1.Ophthalmology topical medicine typically don’t trigger systemic opposed reactions, however could cause short-term improve in intraocular strain, resulting in eye ache, uveitis and corneal edema. Any such glaucoma signs can persist 1 week, and can even result in linear cloudiness of the cornea. Vitritis, iris pigmentation, uveitis, and cracking or delayed therapeutic of wounds. 2.Blood system: chymotrypsin could cause clotting dysfunction.
3.Different: (1) Intramuscular injection could cause anaphylactic shock. (2) chymotrypsin could cause histamine launch, leading to ache and swelling on the native injection website.